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ORIGINAL ARTICLE
Year : 2022  |  Volume : 10  |  Issue : 2  |  Page : 55-62

Raisins preserve thyroid gland function and structure in an animal model of hypercholesterolemia


1 Department of Medical Histology, Faculty of Medicine, Damietta University, Damietta, Egypt; Yousef Abdullatif Jameel, Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
2 Yousef Abdullatif Jameel, Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, King Abdulaziz University, Jeddah; Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Riyadh, Saudi Arabia
3 Medical Intern, Faculty of Medicine, Alfaisal University, Riyadh, Saudi Arabia
4 Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Riyadh, Saudi Arabia
5 Department of Biochemistry, Faculty of Medicine, Mansoura University, Egypt
6 Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Prof. Nasra Ayuob
Department of Medical Histology, Faculty of Medicine, Damietta University, Damietta, Egypt

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmau.jmau_93_20

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Background: Statins are among the first line of pharmacological treatment of lipid disorders and lowering serum cholesterol, but they have many side effects. Aim: The study aim was to evaluate the role of raisins in protecting the thyroid function and structure in a rat model of hypercholesterolemia, through biochemical and histopathological investigation. Materials and Methods: Thirty male rats were randomly divided into three groups (n = 10 each) of albino rats included the control, high cholesterol diet (HCD)-fed for 13 weeks and HCD plus Raisins were included in this study. Blood levels of glucose, insulin, cholesterol, lipids, thyroid-stimulating hormone (TSH), T3, T4, oxidants/anti-oxidants were assessed. Thyroid gland was processed and examined histopathologically using light and electron microscopy. Results: Feeding HCD resulted in hypercholesterolemia in rats after 13 weeks as evidence by lipid profile. Ingestion of raisins along with HCD resulted in a significant (P < 0.001) decrease in the levels of insulin, blood glucose, thyroxine (T4) and malondialdehyde (MDA), while the levels of TSH, T3 and total anti-oxidant capacity significantly (P < 0.001) elevated. Raisins histologically alleviated the HCD-induced structural changes in the thyroid glands that included degenerated mitochondria and increased lipid droplets in the cytoplasm. Conclusions: Simultaneous administration of raisins along with HCD, administrated for a short time, could modulate the negative effect on thyroid gland structure and function.


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