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Work stress, dysbiosis, and immune dysregulation: the interconnected triad in Covid-19 infection in the medical team staff - A mini-review
Shimaa Mohammad Yousof1, Imrana Tanvir2, Eman Kolieb3, Rasha Atta3
1 Department of Medical Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh Branch, Rabigh, Saudi Arabia; Department of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2 Department of Pathology, Faculty of Medicine, King Abdulaziz University, Rabigh Branch, Rabigh, Saudi Arabia
3 Department of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Correspondence Address:
Shimaa Mohammad Yousof,
Department of Medical Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia. Department of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jmau.jmau_9_21
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The COVID-19 pandemic has hit most of the communities around the globe. Earlier researches have reported the psychological effects of pandemics either on the general populations or on specific communities such as students and health professionals. A scanty number of papers have focused on the interaction among complex factors underlying the pathogenesis of the disease. In this review, we aimed to integrate the accessible data about the possible mechanistic processes predisposing to COVID-19 infection in the health professions. We summarized these factors as "stress, microbiota, and immunity triad." We utilized the PubMed database, Google, and Google Scholar search engines to search the literature related to combinations of these keywords: "pandemics, COVID-19, coronavirus, SARS-CoV2;" "gut microbiota, gut-lung axis, dysbiosis, nutrition;" "work stress, workload, health workers, health professions, and medical team;" and "immunity, cytokine storm, and viral load." We detected no discussions combining the suggested triad concerning the medical team personnel. We cast light, for the first time to our knowledge, on the potential pathogenic role of "stress, microbiota, and immunity triad" in COVID-19-infected health workers. |
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