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Pure cutaneous rosai dorfman disease: An uncommon location for a rare histiocytic proliferative disorder
Manjula Jain1, Mukta Pujani1, Dipti Sidam1, Ruchira Wadhwa1, Shanta Passi2, Deepika Uikey2
1 Department of Pathology, ESIC Medical College and Hospital, NIT 3, Faridabad, Haryana, India
2 Department of Dermatology, ESIC Medical College and Hospital, NIT 3, Faridabad, Haryana, India
Correspondence Address:
Mukta Pujani,
Department of Pathology, ESIC Medical College and Hospital, NIT 3, Faridabad, Haryana
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/JMAU.JMAU_76_20
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RosaiDorfman disease (RDD) is a rare, self-limiting disease of uncertain etiology involving lymph nodes as well as extranodal sites. Isolated or pure cutaneous RDD (PCRDD) without lymph node involvement is very unusual accounting for only 3% of all described cases of RDD. The clinical features of PCRDD are quite different from RDD according to the literature on extranodal RDD, thereby emphasizing that PCRDD is a distinct clinical entity. Histopathology remains the gold standard for the diagnosis of both systemic and PCRDD with the presence of characteristic emperipolesis observed in histiocytes while immunohistochemistry (IHC) (S100, CD 68 positive, and CD 1a-negative) serves as a useful adjunct. We hereby report a case of a 36-year-old female who presented with a tender, indurated plaque on the left forearm with a clinical differential diagnosis of borderline tuberculoid leprosy/sarcoidosis and lupus vulgaris. However, on histopathology, a diagnosis of RDD was performed and confirmed on IHC. This case highlights the need to create awareness among young pathologists and clinicians about PCRDD to prevent overzealous treatment.
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