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Conjunctival amyloidosis: A report of two cases with review of literature – 2000–2020
Neha Garg, Preeti Diwaker, Jyotsana Harit Gaur, Malvika Shastri, Sonal Sharma
Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India
Correspondence Address:
Preeti Diwaker,
Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jmau.jmau_88_20
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Amyloidosis is a complex multisystem disorder characterized by deposition of an aberrant protein in tissues and results in disruption of the normal organ function. Localized amyloidosis is a rare disorder. It commonly affects the head-and-neck region, and only 4% of these lesions are encountered in the orbital region. Hence, conjunctival amyloidosis is a very rare entity. It is thought to be a manifestation of local immunologic disorders. Amyloidosis of conjunctiva is more often localized with no other systemic features. Here, we present two cases of unilateral conjunctival amyloidosis, one with extensive calcification. Conjunctival amyloidosis must be considered in the differential diagnosis of conjunctival neoplasms. Histopathological examination and apple-green birefringence on polarized microscopy with Congo red stain remain the gold standard for diagnosing this entity.
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