• Users Online: 2522
  • Print this page
  • Email this page
 
CASE REPORT
Ahead of Print

Clear cell neurofibroma: A rare and confusing variant


 Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt

Correspondence Address:
Asmaa Gaber Abdou,
Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom 32511
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmau.jmau_27_22

Clear cell change has been demonstrated in many cutaneous entities; however, there have been only two reports of clear cell neurofibroma. We present the third case of this unusual subtype. A 25-year-old female presented clinically with a picture of neurofibromatosis Type 1 including multiple cutaneous nodules. Biopsy from one of these nodules revealed a normal epidermal covering and a dermal benign neoplastic growth formed of a mixture of spindle cells and clear cells showing vacuolated cytoplasm. The neoplastic cells showed round nuclei with prominent nucleoli. Immunohistochemical staining showed positivity to S-100 and CD68 with negative expression of calretinin, CK, Melan-A, HMB-45, CD34, and smooth muscle actin. Clear cell neurofibroma should be considered in dealing with clear cell cutaneous lesions, giving attention to characteristic clinical, histopathological, and immunohistochemical features. CD68 could be expressed in neurofibroma, and this should not be misinterpreted as a histiocytic lesion.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Aboelnasr LS
    -  Dawoud MM
    -  Mahmoud SF
    -  Abdou AG
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed73    
    PDF Downloaded2    

Recommend this journal